• FAIL: Another Mammography Study Finds They Don’t Save Lives

  • Vast Study Casts Doubts on Value of Mammograms

     

    study-imageOne of the largest and most meticulous studies of mammography ever done, involving 90,000 women and lasting a quarter-century, has added powerful new doubts about the value of the screening test for women of any age.

    It found that the death rates from breast cancer and from all causes were the same in women who got mammograms and those who did not. And the screening had harms: One in five cancers found with mammography and treated was not a threat to the woman’s health and did not need treatment such as chemotherapy, surgery or radiation.

    The study, published Tuesday in The British Medical Journal, is one of the few rigorous evaluations of mammograms conducted in the modern era of more effective breast cancer treatments. It randomly assigned Canadian women to have regular mammograms and breast exams by trained nurses or to have breast exams alone.

    Researchers sought to determine whether there was any advantage to finding breast cancers when they were too small to feel. The answer is no, the researchers report.

    The study seems likely to lead to an even deeper polarization between those who believe that regular mammography saves lives, including many breast cancer patients and advocates for them, and a growing number of researchers who say the evidence is lacking or, at the very least, murky.

    “It will make women uncomfortable, and they should be uncomfortable,” said Dr. Russell P. Harris, a screening expert and professor of medicine at the University of North Carolina, Chapel Hill, who was not involved in the study. “The decision to have a mammogram should not be a slam dunk.”

    The findings will not lead to any immediate change in guidelines for mammography, and many advocates and experts will almost certainly dispute the idea that mammograms are on balance useless, or even harmful.

    Dr. Richard C. Wender, chief of cancer control for the American Cancer Society, said the society had convened an expert panel that was reviewing all studies on mammography, including the Canadian one, and would issue revised guidelines later this year. He added that combined data from clinical trials of mammography showed it reduces the death rate from breast cancer by at least 15 percent for women in their 40s and by at least 20 percent for older women.

    That means that one woman in 1,000 who starts screening in her 40s, two who start in their 50s and three who start in their 60s will avoid a breast cancer death, Dr. Harris said.

    Dr. Wender added that while improved treatments clearly helped lower the breast cancer death rate, so did mammography, by catching cancers early

    But an editorial accompanying the new study said that earlier studies that found mammograms helped women were done before the routine use of drugs like tamoxifen that sharply reduced the breast cancer death rate. In addition, many studies did not use the gold-standard methods of the clinical trial, randomly assigning women to be screened or not, noted the editorial’s author, Dr. Mette Kalager, and other experts.

    Dr. Kalager, an epidemiologist and screening researcher at the University of Oslo and the Harvard School of Public Health, said there was a reason the results were unlike those of earlier studies. With better treatments, like tamoxifen, it was less important to find cancers early. Also, she said, women in the Canadian study were aware of breast cancer and its dangers, unlike women in earlier studies who were more likely to ignore lumps.

    “It might be possible that mammography screening would work if you don’t have any awareness of the disease,” she said.

    The Canadian study reached the same conclusion about the lack of a benefit from mammograms after 11 to 16 years of follow-up, but some experts predicted that as time went on the advantages would emerge.

    That did not happen, but with more time the researchers could, for the first time, calculate the extent of overdiagnosis, finding cancers that would never have killed the women but that led to treatments that included surgery, chemotherapy and radiation.

    Many cancers, researchers now recognize, grow slowly, or not at all, and do not require treatment. Some cancers even shrink or disappear on their own. But once cancer is detected, it is impossible to know if it is dangerous, so doctors treat them all.

    If the researchers also included a precancerous condition called ductal carcinoma in situ, the overdiagnosis rate would be closer to one in three cancers, said Dr. Anthony B. Miller of the University of Toronto, the lead author of the paper. Ductal carcinoma in situ, or D.C.I.S., is found only with mammography, is confined to the milk duct and may or may not break out into the breast. But it is usually treated with surgery, including mastectomy, or removal of the breast.

    Mammography’s benefits have long been debated, but no nations except Switzerland have suggested the screening be halted. In a recent report, the Swiss Medical Board, an expert panel established by regional ministers of public health, advised that no new mammography programs be started in that country and that those in existence have a limited, though unspecified, duration. Ten of 26 Swiss cantons, or districts, have regular mammography screening programs.

    Dr. Peter Juni, a member of the Swiss Medical Board until recently, said one concern was that mammography was not reducing the overall death rate from the disease, but increasing overdiagnosis and leading to false positives and needless biopsies.

    “The mammography story is just not such an easy story,” said Dr. Juni, a clinical epidemiologist at the University of Bern.

    Even experts like Dr. H. Gilbert Welch, a professor of medicine at Dartmouth, who have questioned mammography’s benefits were surprised by Switzerland’s steps to reconsider its widespread use.

    “Wow, times they are a-changin’,” Dr. Welch said.

    In the United States, about 37 million mammograms are performed annually at a cost of about $100 per mammogram. Nearly three-quarters of women age 40 and over say they had a mammogram in the past year. More than 90 percent of women ages 50 to 69 in several European countries have had at least one mammogram.

    Dr. Kalager, whose editorial accompanying the study was titled “Too Much Mammography,” compared mammography to prostate-specific antigen screening for prostate cancer, using data from pooled analyses of clinical trials. It turned out that the two screening tests were almost identical in their overdiagnosis rate and had almost the same slight reduction in breast or prostate deaths.

    “I was very surprised,” Dr. Kalager said. She had assumed that the evidence for mammography must be stronger since most countries support mammography screening and most discourage PSA screening.

     

     

  • For Women, a More Complicated Choice on Mammograms

  • Annual screening does not reduce risk of death from breast cancer

    Wednesday 12 February 2014 – 12am PST

    Written by David McNamee

    Copyright: Medical News Today

     

    According to a study conducted by researchers in Canada and published in the BMJ, annual screening for breast cancer does not reduce likelihood of dying from cancer any more than physical examination or usual care do in women aged 40-59.

    Cancers of the breast detected in screening (or “mammography”) are, on average, smaller than breast cancers that can be detected through physical examination. And experts know that women with small breast cancers have a better chance of long-term survival than women with large breast cancers.

    But experts cannot be sure that this better chance of survival is because of screening, or if this increased survival is influenced by other factors.

    These include factors called “lead time bias” and “over-diagnosis.” Lead time bias is when testing increases perceived survival time without affecting the course of the disease. Over-diagnosis is the clinical term for the detection of harmless cancers that will not result in symptoms during a patient’s lifetime or cause them to die.

    As breast cancer screening occurs annually for some women as part of an effort to lower breast cancer mortality rates, the researchers behind this new study wanted to measure how effective annual screening is in preventing death from breast cancer.

    “It is true that if you find cancer early it could be at a more treatable stage,” study author Prof. Anthony B. Miller told Medical News Today. “But there is no evidence that early detection affects the inherent biology of the cancer. Indeed it is possible that finding the cancer at an earlier stage will result in undertreatment. There is some evidence that is so.”

    “In our study, and in some other screening studies, those whose cancers were detected by mammography seemed to have more rapidly progressive disease. In addition, the mere fact that a cancer is detected by screening does not guarantee a benefit from detecting that cancer.”

    This was a large, long-term study across six Canadian provinces that followed 89,835 women between the ages of 40 and 59 over a period of 25 years. These women were randomly divided into two groups. The mammography group received one screening every year for 5 years, whereas women in the control group were screened only once.

    Over the entire 25-year study period, a total of 3,250 women in the mammography group and 3,133 in the control group were diagnosed with cancer. In the mammography group, 500 women died, compared with 505 women in the control group. So the mortality rates in both groups were similar.

    The authors say that an excess of 142 cancers were recorded in the mammography group during the 5 years of the screening period, with 106 excess cancers recorded after a period of 15 years. From this, the authors deduce that 22% of the cancers in the mammography group were over-diagnosed.

    “These cancers – comprising half of those found by mammography alone – could not have affected the woman’s lifetime,” said Prof. Miller, “instead there were adverse consequences that she had to endure, living with the knowledge that she had had breast cancer, though in fact that detection did not benefit her at all.”

    “So stopping mammography screening will not result in lives lost, but lives lived with greater quality of that life,” he added.

    What did other studies find?

    In 2013, Medical News Today reported on a UK-based study that also found breast cancer screening does not reduce deaths from the disease.

    But the findings of this study do contradict findings from some other similar studies. A Swedish study attributed a 31% reduction in mortality to mammography. But the authors of the Canadian study think that the Swedish trial was flawed and the difference is down to “an initial imbalance of the compared groups, not a benefit of screening mammography.”

    A large systematic review of data from 1976 to 2008 also had different findings to the Canadian study, estimating that 31% of all breast cancers were over-diagnosed. The Canadian researchers think this difference was due to that review taking a wider age range into account than their study, which looked at women between the ages of 40 and 59 only. They think that over-diagnosis is more common in people older than this, as there are more potential causes of death as individuals age.

    The researchers also admit that the result of the Canadian study may not be generalizable to all countries.

    Rationale for mammography should be ‘reassessed’

    Although Prof. Miller and his team assert that education, early diagnosis and clinical care remain priorities in treating breast cancer, they say that mammography does not result in a reduction in breast cancer-specific mortality for women aged 40-59 beyond that of physical examination alone or usual care in the community.

    The authors say that annual breast cancer screening should be urgently reassessed by policy makers, but they anticipate resistance from medical groups with “vested interests.”

    Prof. Miller told Medical News Today:

    “The greatest resistance will come from radiologists, who are convinced that finding cancers results in benefit, and who also benefit financially from that belief. We have demonstrated that is not so. Others whose advice resulted in the establishment of breast screening programs will also feel threatened.

    It is unfortunate that although we maintain we should practice evidence-based medicine, when that evidence is produced, there will be many who will seek the means to discredit that evidence because it is against their vested interests.”

    Rather than annual breast screenings, the authors of the study would like to see funding diverted into better public education programs to convince women to seek skilled advice if they detect an abnormality in their breast, and professional education programs that ensure doctors are familiar with the latest advances in research.