EVALUATION OF THE ABILITY OF DIGITAL INFRARED IMAGING TO DETECT VASCULAR CHANGES IN EXPERIMENTAL ANIMAL TUMOURS

Int. J. Cancer: 108, 790–794 (2004)

© 2003 Wiley-Liss, Inc.

Publication of the International Union Against Cancer

Infrared imaging has frequently been used in the past to detect changes in skin surface temperature associated with breast cancer. Usually a 1–2° C elevation in skin surfacet em-perature is observed at the tumour periphery, and it has been proposed that this change is due to hypervascularity resulting from tumour-associated angiogenesis. In our study, we used the rat mammary adenocarcinoma 13762 MAT, a tumour that has been used to identify antiangiogenic drugs, to investigate whether infrared imaging can detect angiogenesis in malignant tumours. If successful, it was hoped that this technique would represent a simple, noninvasive, procedure for monitoring the activity of antiangiogenic drugs. To read the rest of this article, click here to download the PDF file of this study.

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